2qdz: Difference between revisions

Line 4:

==Overview==

In Gram-negative bacteria and eukaryotic organelles, beta-barrel proteins, of the outer membrane protein 85-two-partner secretion B (Omp85-TpsB), superfamily are essential components of protein transport machineries. The, TpsB transporter FhaC mediates the secretion of Bordetella pertussis, filamentous hemagglutinin (FHA). We report the 3.15 A crystal structure of, FhaC. The transporter comprises a 16-stranded beta barrel that is occluded, by an N-terminal alpha helix and an extracellular loop and a periplasmic, module composed of two aligned polypeptide-transport-associated (POTRA), domains. Functional data reveal that FHA binds to the POTRA 1 domain via, its N-terminal domain and likely translocates the adhesin-repeated motifs, in an extended hairpin conformation, with folding occurring at the cell, surface. General features of the mechanism obtained here are likely to, apply throughout the superfamily.

In Gram-negative bacteria and eukaryotic organelles, beta-barrel proteins of the outer membrane protein 85-two-partner secretion B (Omp85-TpsB) superfamily are essential components of protein transport machineries. The TpsB transporter FhaC mediates the secretion of Bordetella pertussis filamentous hemagglutinin (FHA). We report the 3.15 A crystal structure of FhaC. The transporter comprises a 16-stranded beta barrel that is occluded by an N-terminal alpha helix and an extracellular loop and a periplasmic module composed of two aligned polypeptide-transport-associated (POTRA) domains. Functional data reveal that FHA binds to the POTRA 1 domain via its N-terminal domain and likely translocates the adhesin-repeated motifs in an extended hairpin conformation, with folding occurring at the cell surface. General features of the mechanism obtained here are likely to apply throughout the superfamily.

==About this Structure==

Line 21:

[[Category: protein transport]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jan 23 13~~:43:50 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:38:30 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 4: / Line 4: @@
 ==Overview==
-In Gram-negative bacteria and eukaryotic organelles, beta-barrel proteins, of the outer membrane protein 85-two-partner secretion B (Omp85-TpsB), superfamily are essential components of protein transport machineries. The, TpsB transporter FhaC mediates the secretion of Bordetella pertussis, filamentous hemagglutinin (FHA). We report the 3.15 A crystal structure of, FhaC. The transporter comprises a 16-stranded beta barrel that is occluded, by an N-terminal alpha helix and an extracellular loop and a periplasmic, module composed of two aligned polypeptide-transport-associated (POTRA), domains. Functional data reveal that FHA binds to the POTRA 1 domain via, its N-terminal domain and likely translocates the adhesin-repeated motifs, in an extended hairpin conformation, with folding occurring at the cell, surface. General features of the mechanism obtained here are likely to, apply throughout the superfamily.
+In Gram-negative bacteria and eukaryotic organelles, beta-barrel proteins of the outer membrane protein 85-two-partner secretion B (Omp85-TpsB) superfamily are essential components of protein transport machineries. The TpsB transporter FhaC mediates the secretion of Bordetella pertussis filamentous hemagglutinin (FHA). We report the 3.15 A crystal structure of FhaC. The transporter comprises a 16-stranded beta barrel that is occluded by an N-terminal alpha helix and an extracellular loop and a periplasmic module composed of two aligned polypeptide-transport-associated (POTRA) domains. Functional data reveal that FHA binds to the POTRA 1 domain via its N-terminal domain and likely translocates the adhesin-repeated motifs in an extended hairpin conformation, with folding occurring at the cell surface. General features of the mechanism obtained here are likely to apply throughout the superfamily.
 ==About this Structure==
@@ Line 21: / Line 21: @@
 [[Category: protein transport]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:43:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:38:30 2008''