4i0i: Difference between revisions
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{{STRUCTURE_4i0i| PDB=4i0i | SCENE= }} | |||
===SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
==About this Structure== | |||
[[4i0i]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0I OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Memapsin 2]] | |||
[[Category: Brecht, E.]] | |||
[[Category: Yao, N.]] | |||
[[Category: Aspartic protease]] | |||
[[Category: Bace]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Hydrolysis]] | |||
Revision as of 13:42, 20 November 2013
SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors
Function
[BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.[1] [2]
About this Structure
4i0i is a 3 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1456-60. PMID:10677483
- ↑ Okada H, Zhang W, Peterhoff C, Hwang JC, Nixon RA, Ryu SH, Kim TW. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J. 2010 Aug;24(8):2783-94. doi: 10.1096/fj.09-146357. Epub 2010 Mar 30. PMID:20354142 doi:10.1096/fj.09-146357
