Sandbox Reserved 779: Difference between revisions
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==Introduction == | ==Introduction == | ||
β-Lactoglobulin (β-LG)is the major whey protein of ruminant species and is also present in the milks of many, but not all, other species. Its amino-acid sequence and 3-dimensional structure show that it is a lipocalin, a widely diverse family, most of which bind small hydrophobic ligands and thus may act as specific transporters, as does serum retinol binding protein <ref>PMID:15259212</ref>. | |||
β-Lactoglobulin is a small protein, soluble in dilute salt solution as befits a globulin, with 162 amino acid residues (Mr ∼18,400) that fold up into an 8-stranded, antiparallel β-barrel with a 3-turn α-helix on the outer surface and a ninth β-strand flanking the first strand (see Figure 1). It is this strand that forms a significant part of the dimer interface in the bovine and bovine proteins but, while still present in porcine β-LG, is not involved in the formation of the dimer that forms at low pH. | |||
Function:Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.<ref>PMID:15259212</ref>. | Function:Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.<ref>PMID:15259212</ref>. | ||
