Sandbox Reserved 779: Difference between revisions
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Rini Triani (talk | contribs) No edit summary |
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==Relevant background == | ===Relevant background === | ||
class of protein :Belongs to the calycin superfamily. Lipocalin family. | class of protein :Belongs to the calycin superfamily. Lipocalin family. | ||
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organisms:These proteins are found in gram negative bacteria, vertebrate cells, and invertebrate cells, and in plants. | organisms:These proteins are found in gram negative bacteria, vertebrate cells, and invertebrate cells, and in plants. | ||
==Lipocalin Proteins== | ===Lipocalin Proteins=== | ||
The merlin-1 protein belongs to the band 4.1 superfamily of membrane-cytoskeletal linkers <ref>PMID:8242753</ref>. | The merlin-1 protein belongs to the band 4.1 superfamily of membrane-cytoskeletal linkers <ref>PMID:8242753</ref>. | ||
Within this superfamily merlin-1 is closer to ezrin,radixin and moesin (the ERM proteins). | Within this superfamily merlin-1 is closer to ezrin,radixin and moesin (the ERM proteins). | ||
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d. description of any ligands in the structure | d. description of any ligands in the structure | ||
e. methods used to solve the structure : X-ray crystallography, NMR, EM | e. methods used to solve the structure : X-ray crystallography, NMR, EM | ||
==Subunit structure== | |||
Under physiological conditions beta-lactoglobulin exists as an equilibrium mixture of monomeric and dimeric forms. | |||
Subcellular location: Secreted. | |||
Tissue specificity: Synthesized in mammary gland and secreted in milk. | |||
Post-translational modification : Alternate disulfide bonds occur in equal amounts in all variants examined. | |||
Allergenic properties:Causes an allergic reaction in human. Is one of the causes of cow's milk allergy. | |||
Miscellaneous The B variant sequence is shown. | |||
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[[Image:inactivestate.gif |thumb|left|650px|Inactive ERM protein]][[Image:active2.gif |thumb|right|650px|Active ERM protein]] | [[Image:inactivestate.gif |thumb|left|650px|Inactive ERM protein]][[Image:active2.gif |thumb|right|650px|Active ERM protein]] | ||
