4c8t: Difference between revisions
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{{STRUCTURE_4c8t| PDB=4c8t | SCENE= }} | {{STRUCTURE_4c8t| PDB=4c8t | SCENE= }} | ||
===Xenopus ZNRF3 ectodomain crystal form I=== | ===Xenopus ZNRF3 ectodomain crystal form I=== | ||
{{ABSTRACT_PUBMED_24225776}} | |||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4c8t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8T OCA]. | [[4c8t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8T OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:024225776</ref><references group="xtra"/><references/> | |||
[[Category: Jones, E Y.]] | [[Category: Jones, E Y.]] | ||
[[Category: Zebisch, M.]] | [[Category: Zebisch, M.]] | ||
Revision as of 08:55, 27 November 2013
Xenopus ZNRF3 ectodomain crystal form I
Template:ABSTRACT PUBMED 24225776
Function
[ZNRF3_XENTR] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity).
About this Structure
4c8t is a 2 chain structure with sequence from Silurana (xenopus) tropicalis. Full crystallographic information is available from OCA.
Reference
- Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY. Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776 doi:https://dx.doi.org/10.1038/ncomms3787
