4bsq: Difference between revisions
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{{STRUCTURE_4bsq| PDB=4bsq | SCENE= }} | |||
===MOUSE CATHEPSIN S WITH COVALENT LIGAND=== | |||
{{ABSTRACT_PUBMED_24224654}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/CATS_MOUSE CATS_MOUSE]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. | |||
==About this Structure== | |||
[[4bsq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSQ OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024224654</ref><references group="xtra"/><references/> | |||
[[Category: Cathepsin S]] | |||
[[Category: Banner, D W.]] | |||
[[Category: Benz, J.]] | |||
[[Category: Gsell, B.]] | |||
[[Category: Hilpert, H.]] | |||
[[Category: Ruf, A.]] | |||
[[Category: Stihle, M.]] | |||
[[Category: Cysteine protease]] | |||
[[Category: Hydrolase]] | |||
Revision as of 10:21, 27 November 2013
MOUSE CATHEPSIN S WITH COVALENT LIGAND
Template:ABSTRACT PUBMED 24224654
Function
[CATS_MOUSE] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
About this Structure
4bsq is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Hilpert H, Mauser H, Humm R, Anselm L, Kuehne H, Hartmann G, Gruener S, Banner DW, Benz J, Gsell B, Kuglstatter A, Stihle M, Thoma R, Sanchez RA, Iding H, Wirz B, Haap W. Identification of Potent and Selective Cathepsin S Inhibitors Containing Different Central Cyclic Scaffolds. J Med Chem. 2013 Nov 22. PMID:24224654 doi:https://dx.doi.org/10.1021/jm401528k
