4guo: Difference between revisions
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{{STRUCTURE_4guo| PDB=4guo | SCENE= }} | |||
===structure of p73 DNA binding domain complex with 12 bp DNA=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> | |||
==About this Structure== | |||
[[4guo]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUO OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Ethayathulla, A S]] | |||
[[Category: Viadiu, H.]] | |||
[[Category: Beta-immunoglobulin fold]] | |||
[[Category: Dna]] | |||
[[Category: Dna binding]] | |||
[[Category: Transcription factor]] | |||
[[Category: Transcription-dna complex]] | |||
[[Category: Tumor suppressor]] | |||
Revision as of 10:29, 27 November 2013
structure of p73 DNA binding domain complex with 12 bp DNA
Function
[P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.[1] [2] [3]
About this Structure
4guo is a 16 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Grob TJ, Novak U, Maisse C, Barcaroli D, Luthi AU, Pirnia F, Hugli B, Graber HU, De Laurenzi V, Fey MF, Melino G, Tobler A. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 2001 Dec;8(12):1213-23. PMID:11753569 doi:10.1038/sj.cdd.4400962
- ↑ Kaelin WG Jr. The emerging p53 gene family. J Natl Cancer Inst. 1999 Apr 7;91(7):594-8. PMID:10203277
- ↑ Koida N, Ozaki T, Yamamoto H, Ono S, Koda T, Ando K, Okoshi R, Kamijo T, Omura K, Nakagawara A. Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. J Biol Chem. 2008 Mar 28;283(13):8555-63. doi: 10.1074/jbc.M710608200. Epub 2008 , Jan 3. PMID:18174154 doi:10.1074/jbc.M710608200
