4msv: Difference between revisions
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{{STRUCTURE_4msv| PDB=4msv | SCENE= }} | |||
===Crystal structure of FASL and DcR3 complex=== | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Autoimmune lymphoproliferative syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> [[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.<ref>PMID:17557115</ref> The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.<ref>PMID:17557115</ref> | |||
==About this Structure== | |||
[[4msv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSV OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Almo, S C.]] | |||
[[Category: Bhosle, R C.]] | |||
[[Category: Bonanno, J B.]] | |||
[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]] | |||
[[Category: Liu, W.]] | |||
[[Category: NYSGRC, New York Structural Genomics Research Consortium.]] | |||
[[Category: Nathenson, S G.]] | |||
[[Category: Ramagopal, U A.]] | |||
[[Category: Zhan, C.]] | |||
[[Category: Atoms-to-animals: the immune function network]] | |||
[[Category: Bind tnf receptor fa]] | |||
[[Category: Cd95l]] | |||
[[Category: Cytokine]] | |||
[[Category: Dcr3]] | |||
[[Category: Fas ligand]] | |||
[[Category: Fasl]] | |||
[[Category: Ifn]] | |||
[[Category: Immune system]] | |||
[[Category: Immunity]] | |||
[[Category: Jelly-roll fold]] | |||
[[Category: Membrane]] | |||
[[Category: New york structural genomic]] | |||
[[Category: New york structural genomics research consortium]] | |||
[[Category: Nysgrc]] | |||
[[Category: Protein structure initiative]] | |||
[[Category: Psi-biology]] | |||
[[Category: Research consortium]] | |||
[[Category: Secreted protein]] | |||
[[Category: Structural genomic]] | |||
[[Category: Tnf]] | |||
[[Category: Tnf supe cd95l]] | |||
[[Category: Tnf superfamily]] | |||
[[Category: Tnf6]] | |||
[[Category: Tnfr]] | |||
