Sandbox Reserved 773: Difference between revisions
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'''Histidine Decarboxylase (HDC)''' is an enzyme that is responsible for converting histamine from amino acid L-histidine. This enzyme belongs in the group II pyridoxal-5-phosphate (PLP)-dependent decarboxylase family <ref name=fun/>. As the name suggested, this enzyme catalyzes the production of histamine by the removal of carboxylate group from the amino acid L-histidine whilst utilizes on pyridoxal phosphate as a cofactor <ref name=metabolism/> | '''Histidine Decarboxylase (HDC)''' is an enzyme that is responsible for converting histamine from amino acid L-histidine. This enzyme belongs in the group II pyridoxal-5-phosphate (PLP)-dependent decarboxylase family <ref name=fun/>. As the name suggested, this enzyme catalyzes the production of histamine by the removal of carboxylate group from the amino acid L-histidine whilst utilizes on pyridoxal phosphate as a cofactor <ref name=metabolism/> | ||
The mammalian Histamine decarboxylase is originated from HDC gene which encodes a 74kDa precursor polypeptide <ref name=tag>PMID: 6425286</ref>. However, the enzyme becomes active after undergo post-translation proteolysis when its C-terminal is truncated into 54kDa <ref name=metabolism>Schwelberger, Hubert G. "Metabolism of Histamine." ''European Histamine Research Society'' Nov. 2013. Web. 29 Nov. 2013. http://www.ehrs.org.uk/schwelberger.pdf</ref> <ref name=jbc/>. | The mammalian Histamine decarboxylase is originated from HDC gene which encodes a 74kDa precursor polypeptide <ref name=tag>PMID: 6425286</ref>. However, the enzyme becomes active after undergo post-translation proteolysis when its C-terminal is truncated into 54kDa <ref name=metabolism>Schwelberger, Hubert G. "Metabolism of Histamine." ''European Histamine Research Society'' Nov. 2013. Web. 29 Nov. 2013. http://www.ehrs.org.uk/schwelberger.pdf</ref> <ref name=jbc/>. | ||
Due to the fact that histamine is a mediator that triggers inflammation response associated with allergic reaction, HDC an important enzyme to study for the development of drugs or treatments for allergic disease <ref name=fun>PMID: 15612036</ref> <ref name=metabolism/>. | Due to the fact that histamine is a mediator that triggers inflammation response associated with allergic reaction, HDC an important enzyme to study for the development of drugs or treatments for allergic disease <ref name=fun>PMID: 15612036</ref> <ref name=metabolism/>. | ||
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