Sandbox Reserved 772: Difference between revisions
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[[Image:pathways.jpg]] | [[Image:pathways.jpg]] | ||
This bifunctional enzyme converts L-histidinol to L-histidine through a L-histidinaldehyde intermediate. <ref name="pnas">http://www.pnas.org.prox.lib.ncsu.edu/content/99/4/1859.full.pdf</ref> | This bifunctional enzyme converts L-histidinol to L-histidine through a L-histidinaldehyde intermediate. The process is as follows: | ||
-extraction of one proton and one hydride from L-histidinol[1] | |||
-reduced NADH leaves and replaced by NAD+ | |||
-repeat the first step | |||
-His-327 abstracts a proton from the hydroxyl group, and the second NAD+ molecule is reduced by a hydride | |||
-formation of l-histidine.<ref name="pnas">http://www.pnas.org.prox.lib.ncsu.edu/content/99/4/1859.full.pdf</ref> | |||
==Implications or Possible Applications== | ==Implications or Possible Applications== | ||
