Sandbox Reserved 773: Difference between revisions

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[[Image:4e1o asr r 500.jpg|frame|right|Figure 1. Asymmetrical unit of Histidine Decarboxylase formed by 3 homodimer-subunits)]]

'''Histidine Decarboxylase (HDC)''' is an enzyme that is responsible for converting histamine from amino acid L-histidine. This enzyme ~~belongs~~ in the group II pyridoxal-5-phosphate (PLP)-dependent decarboxylase family <ref name=fun/>. As the name suggested, this enzyme catalyzes the production of histamine by the removal of carboxylate group from the amino acid L-histidine whilst utilizes on pyridoxal phosphate as a cofactor <ref name=metabolism/>

'''Histidine Decarboxylase (HDC)''' is an enzyme that is responsible for converting histamine from amino acid L-histidine. This enzyme belong in the group II pyridoxal-5-phosphate (PLP)-dependent decarboxylase family <ref name=fun/>. As the name suggested, this enzyme catalyzes the production of histamine by the removal of carboxylate group from the amino acid L-histidine whilst utilizes on pyridoxal phosphate as a cofactor <ref name=metabolism/>. Since this enzyme breaks the carbon-carbon bond to produce carbon dioxide (CO2), it is in class IV lyase.

The mammalian Histamine decarboxylase is originated from HDC gene which encodes a 74kDa precursor polypeptide <ref name=tag>PMID: 6425286</ref>. However, the enzyme becomes active after undergo post-translation proteolysis when its C-terminal is truncated into 54kDa <ref name=metabolism>Schwelberger, Hubert G. "Metabolism of Histamine." ''European Histamine Research Society'' Nov. 2013. Web. 29 Nov. 2013. http://www.ehrs.org.uk/schwelberger.pdf</ref> <ref name=jbc/>.

The mammalian Histamine decarboxylase is originated from HDC gene which in found in the human chromosome 15. This gene encodes a 74kDa precursor polypeptide <ref name=tag>PMID: 6425286</ref>. However, the enzyme becomes active after undergo post-translation proteolysis when its C-terminal is truncated into 54kDa <ref name=metabolism>Schwelberger, Hubert G. "Metabolism of Histamine." ''European Histamine Research Society'' Nov. 2013. Web. 29 Nov. 2013. http://www.ehrs.org.uk/schwelberger.pdf</ref> <ref name=jbc/>.

Sandbox Reserved 773: Difference between revisions

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 [[Image:4e1o asr r 500.jpg|frame|right|Figure 1. Asymmetrical unit of Histidine Decarboxylase formed by 3 homodimer-subunits)]]
-'''Histidine Decarboxylase (HDC)''' is an enzyme that is responsible for converting histamine from amino acid L-histidine. This enzyme belongs in the group II pyridoxal-5-phosphate (PLP)-dependent decarboxylase family <ref name=fun/>. As the name suggested, this enzyme catalyzes the production of histamine by the removal of carboxylate group from the amino acid L-histidine whilst utilizes on pyridoxal phosphate as a cofactor <ref name=metabolism/>
+'''Histidine Decarboxylase (HDC)''' is an enzyme that is responsible for converting histamine from amino acid L-histidine. This enzyme belong in the group II pyridoxal-5-phosphate (PLP)-dependent decarboxylase family <ref name=fun/>. As the name suggested, this enzyme catalyzes the production of histamine by the removal of carboxylate group from the amino acid L-histidine whilst utilizes on pyridoxal phosphate as a cofactor <ref name=metabolism/>. Since this enzyme breaks the carbon-carbon bond to produce carbon dioxide (CO2), it is in class IV lyase.
-The mammalian Histamine decarboxylase is originated from HDC gene which encodes a 74kDa precursor polypeptide <ref name=tag>PMID: 6425286</ref>. However, the enzyme becomes active after undergo post-translation proteolysis when its C-terminal is truncated into 54kDa <ref name=metabolism>Schwelberger, Hubert G. "Metabolism of Histamine." ''European Histamine Research Society'' Nov. 2013. Web. 29 Nov. 2013. http://www.ehrs.org.uk/schwelberger.pdf</ref> <ref name=jbc/>.
+The mammalian Histamine decarboxylase is originated from HDC gene which in found in the human chromosome 15. This gene encodes a 74kDa precursor polypeptide <ref name=tag>PMID: 6425286</ref>. However, the enzyme becomes active after undergo post-translation proteolysis when its C-terminal is truncated into 54kDa <ref name=metabolism>Schwelberger, Hubert G. "Metabolism of Histamine." ''European Histamine Research Society'' Nov. 2013. Web. 29 Nov. 2013. http://www.ehrs.org.uk/schwelberger.pdf</ref> <ref name=jbc/>.