2w98: Difference between revisions
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{{STRUCTURE_2w98| PDB=2w98 | SCENE= }} | {{STRUCTURE_2w98| PDB=2w98 | SCENE= }} | ||
===CRYSTAL STRUCTURE OF HUMAN ZINC-BINDING ALCOHOL DEHYDROGENASE 1 (ZADH1) IN TERNARY COMPLEX WITH NADP AND PHENYLBUTAZONE=== | ===CRYSTAL STRUCTURE OF HUMAN ZINC-BINDING ALCOHOL DEHYDROGENASE 1 (ZADH1) IN TERNARY COMPLEX WITH NADP AND PHENYLBUTAZONE=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/PTGR2_HUMAN PTGR2_HUMAN]] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).<ref>PMID:19000823</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2w98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[2w98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W98 OCA]. | ||
==See Also== | ==See Also== | ||
*[[Alcohol dehydrogenase|Alcohol dehydrogenase]] | *[[Alcohol dehydrogenase|Alcohol dehydrogenase]] | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: 15-oxoprostaglandin 13-oxidase]] | [[Category: 15-oxoprostaglandin 13-oxidase]] | ||
[[Category: | [[Category: Human]] | ||
[[Category: Arrowsmith, C.]] | [[Category: Arrowsmith, C.]] | ||
[[Category: Bountra, C.]] | [[Category: Bountra, C.]] | ||
Revision as of 06:03, 4 December 2013
CRYSTAL STRUCTURE OF HUMAN ZINC-BINDING ALCOHOL DEHYDROGENASE 1 (ZADH1) IN TERNARY COMPLEX WITH NADP AND PHENYLBUTAZONE
Function
[PTGR2_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).[1]
About this Structure
2w98 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See Also
Reference
- ↑ Wu YH, Ko TP, Guo RT, Hu SM, Chuang LM, Wang AH. Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2. Structure. 2008 Nov 12;16(11):1714-23. PMID:19000823 doi:10.1016/j.str.2008.09.007
