4c4f: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4c4f|  PDB=4c4f  |  SCENE=  }}
===Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1===
{{ABSTRACT_PUBMED_24256217}}


The entry 4c4f is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>  


Authors: Naud, S., Westwood, I.M., Faisal, A., Sheldrake, P., Bavetsias, V., Atrash, B., Liu, M., Hayes, A., Schmitt, J., Wood, A., Choi, V., Boxall, K., Mak, G., Gurden, M., Valenti, M., de Haven Brandon, A., Henley, A., Baker, R., McAndrew, C., Matijssen, B., Burke, R., Eccles, S.A., Raynaud, F.I., Linardopoulos, S., van Montfort, R., Blagg, J.
==About this Structure==
[[4c4f]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C4F OCA].  


Description: Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1
==Reference==
<ref group="xtra">PMID:024256217</ref><references group="xtra"/><references/>
[[Category: Dual-specificity kinase]]
[[Category: Atrash, B.]]
[[Category: Baker, R.]]
[[Category: Bavetsias, V.]]
[[Category: Blagg, J.]]
[[Category: Boxall, K.]]
[[Category: Brandon, A de Haven.]]
[[Category: Burke, R.]]
[[Category: Choi, V.]]
[[Category: Eccles, S A.]]
[[Category: Faisal, A.]]
[[Category: Gurden, M.]]
[[Category: Hayes, A.]]
[[Category: Henley, A.]]
[[Category: Linardopoulos, S.]]
[[Category: Liu, M.]]
[[Category: Mak, G.]]
[[Category: Matijssen, B.]]
[[Category: McAndrew, C.]]
[[Category: Montfort, R van.]]
[[Category: Naud, S.]]
[[Category: Raynaud, F I.]]
[[Category: Schmitt, J.]]
[[Category: Sheldrake, P.]]
[[Category: Valenti, M.]]
[[Category: Westwood, I M.]]
[[Category: Wood, A.]]
[[Category: Mitosis]]
[[Category: Protein kinase]]
[[Category: Structure-based design]]
[[Category: Transferase]]
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