4c2f: Difference between revisions
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{{STRUCTURE_4c2f| PDB=4c2f | SCENE= }} | |||
===Crystal structure of the CtpB R168A mutant present in an active conformation=== | |||
{{ABSTRACT_PUBMED_24243021}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/CTPB_BACSU CTPB_BACSU]] Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.<ref>PMID:14526016</ref> <ref>PMID:16818230</ref> <ref>PMID:17557826</ref> | |||
==About this Structure== | |||
[[4c2f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2F OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024243021</ref><references group="xtra"/><references/> | |||
[[Category: C-terminal processing peptidase]] | |||
[[Category: Escherichia coli]] | |||
[[Category: Clausen, T.]] | |||
[[Category: Heuck, A.]] | |||
[[Category: Kurzbauer, R.]] | |||
[[Category: Mastny, M.]] | |||
[[Category: Hydrolase]] | |||
[[Category: Proteolytic tunnel]] | |||
Revision as of 07:22, 4 December 2013
Crystal structure of the CtpB R168A mutant present in an active conformation
Template:ABSTRACT PUBMED 24243021
Function
[CTPB_BACSU] Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.[1] [2] [3]
About this Structure
4c2f is a 3 chain structure with sequence from [1] and Escherichia coli. Full crystallographic information is available from OCA.
Reference
- Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T. CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis. Cell. 2013 Oct 24;155(3):647-58. doi: 10.1016/j.cell.2013.09.050. Epub 2013 Oct, 24. PMID:24243021 doi:https://dx.doi.org/10.1016/j.cell.2013.09.050
- ↑ Pan Q, Losick R, Rudner DZ. A second PDZ-containing serine protease contributes to activation of the sporulation transcription factor sigmaK in Bacillus subtilis. J Bacteriol. 2003 Oct;185(20):6051-6. PMID:14526016
- ↑ Campo N, Rudner DZ. A branched pathway governing the activation of a developmental transcription factor by regulated intramembrane proteolysis. Mol Cell. 2006 Jul 7;23(1):25-35. PMID:16818230 doi:https://dx.doi.org/10.1016/j.molcel.2006.05.019
- ↑ Campo N, Rudner DZ. SpoIVB and CtpB are both forespore signals in the activation of the sporulation transcription factor sigmaK in Bacillus subtilis. J Bacteriol. 2007 Aug;189(16):6021-7. Epub 2007 Jun 8. PMID:17557826 doi:https://dx.doi.org/10.1128/JB.00399-07
