2m7q: Difference between revisions
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{{STRUCTURE_2m7q| PDB=2m7q | SCENE= }} | |||
===Solution structure of TAX1BP1 UBZ1+2=== | |||
{{ABSTRACT_PUBMED_24239949}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TAXB1_HUMAN TAXB1_HUMAN]] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.<ref>PMID:10435631</ref> <ref>PMID:10920205</ref> | |||
==About this Structure== | |||
[[2m7q]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7Q OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024239949</ref><references group="xtra"/><references/> | |||
[[Category: Amilibia, M Spinola.]] | |||
[[Category: Bravo, J.]] | |||
[[Category: Buts, L.]] | |||
[[Category: Ceregido, M A.]] | |||
[[Category: Nuland, N A.J van.]] | |||
[[Category: Metal binding protein]] | |||
[[Category: Tax1bp1]] | |||
[[Category: Ubd]] | |||
[[Category: Ubz domain]] | |||
[[Category: Zinc finger domain]] | |||
Revision as of 07:22, 4 December 2013
Solution structure of TAX1BP1 UBZ1+2
Template:ABSTRACT PUBMED 24239949
Function
[TAXB1_HUMAN] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.[1] [2]
About this Structure
2m7q is a 1 chain structure. Full experimental information is available from OCA.
Reference
- Ceregido MA, Spinola Amilibia M, Buts L, Rivera-Torres J, Garcia-Pino A, Bravo J, van Nuland NA. The Structure of TAX1BP1 UBZ1+2 Provides Insight into Target Specificity and Adaptability. J Mol Biol. 2013 Nov 13. pii: S0022-2836(13)00717-1. doi:, 10.1016/j.jmb.2013.11.006. PMID:24239949 doi:https://dx.doi.org/10.1016/j.jmb.2013.11.006
- ↑ De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene. 1999 Jul 22;18(29):4182-90. PMID:10435631 doi:https://dx.doi.org/10.1038/sj.onc.1202787
- ↑ Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9567-72. PMID:10920205 doi:https://dx.doi.org/10.1073/pnas.170279097
