3zjb: Difference between revisions
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{{STRUCTURE_3zjb| PDB=3zjb | SCENE= }} | |||
===The structure of the TRAF domain of human TRAF4=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref> | |||
==About this Structure== | |||
[[3zjb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJB OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Alpy, F.]] | |||
[[Category: McEwen, A G.]] | |||
[[Category: Nomine, Y.]] | |||
[[Category: Poussin-Courmontagne, P.]] | |||
[[Category: Rio, M C.]] | |||
[[Category: Rogna, D.]] | |||
[[Category: Rousseau, A.]] | |||
[[Category: Tomasetto, C.]] | |||
[[Category: Signaling protein]] | |||