Pregnane X receptor: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='1skx' size='350' side='right' caption='Structure of human pregnane X receptor LBD complex with antibiotic (PDB entry 1skx)' scene=''> '''Pregnane X receptor''... |
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<StructureSection load='1skx' size='350' side='right' caption='Structure of human pregnane X receptor LBD complex with antibiotic rifampicin (PDB entry [[1skx]])' scene=''> | |||
'''Pregnane X receptor''' (PXR) is a nuclear receptor which senses the presence of toxic substances and regulates the expression of proteins which are involved in detoxificaton. PXR is activated by a large range of steroids, antibiotics, bile acids and many herbal compounds. Thus it is a generalized sensor of hydrophobic toxins. When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA. PXR, similar to other nuclear receptors contains a ligand-binding domain (LBD) and DNA-binding domain (DBD). | |||
==3D structures of pregnane X receptor== | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[1ilg]] – hPXR LBD – human<br /> | [[1ilg]] – hPXR LBD – human<br /> | ||
