Pregnane X receptor: Difference between revisions

Line 1:

'''Pregnane X receptor''' (PXR) is a ~~nuclear~~ receptor which senses the presence of toxic substances and regulates the expression of proteins which are involved in detoxificaton. PXR is activated by a large range of steroids, antibiotics, bile acids and many herbal compounds. Thus it is a generalized sensor of hydrophobic toxins. When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA. PXR, similar to other nuclear receptors contains a ligand-binding domain (LBD) and DNA-binding domain (DBD).

'''Pregnane X receptor''' (PXR) is a [[Nuclear receptor]] which senses the presence of toxic substances and regulates the expression of proteins which are involved in detoxificaton. PXR is activated by a large range of steroids, antibiotics, bile acids and many herbal compounds. Thus it is a generalized sensor of hydrophobic toxins. When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA. PXR, similar to other nuclear receptors contains a ligand-binding domain (LBD) and DNA-binding domain (DBD).

==3D structures of pregnane X receptor==

Pregnane X receptor: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
 <StructureSection load='1skx' size='350' side='right' caption='Structure of human pregnane X receptor LBD complex with antibiotic rifampicin (PDB entry [[1skx]])' scene=''>
-'''Pregnane X receptor''' (PXR) is a nuclear receptor which senses the presence of toxic substances and regulates the expression of proteins which are involved in detoxificaton.  PXR is activated by a large range of steroids, antibiotics, bile acids and many herbal compounds.  Thus it is a generalized sensor of hydrophobic toxins.  When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA.  PXR, similar to other nuclear receptors contains a ligand-binding domain (LBD) and DNA-binding domain (DBD).
+'''Pregnane X receptor''' (PXR) is a [[Nuclear receptor]] which senses the presence of toxic substances and regulates the expression of proteins which are involved in detoxificaton.  PXR is activated by a large range of steroids, antibiotics, bile acids and many herbal compounds.  Thus it is a generalized sensor of hydrophobic toxins.  When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA.  PXR, similar to other nuclear receptors contains a ligand-binding domain (LBD) and DNA-binding domain (DBD).
 ==3D structures of pregnane X receptor==