Sandbox Reserved 777: Difference between revisions
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== Viral IL-10 == | == Viral IL-10 == | ||
Viral homologs to Il-10 have been found in Epstein-Barr virus (EBV), human cytomegalovirus (hCMV) and multiple other members of the Herpesvirales and Poxviridae families of viruses. These viruses likely acquired IL-10 encoding sequences from their hosts and, when expressed, produce vIL-10 with enough similarity to host IL-10 that they can bind to IL-10R1 and start the signaling cascade. The result is the suppression of immune functions and enhancement of infection.'''(12)''' | Viral homologs to Il-10 have been found in Epstein-Barr virus (EBV), human cytomegalovirus (hCMV) and multiple other members of the Herpesvirales and Poxviridae families of viruses. These viruses likely acquired IL-10 encoding sequences from their hosts and, when expressed, produce vIL-10 with enough similarity to host IL-10 that they can bind to IL-10R1 and start the signaling cascade. The result is the suppression of immune functions and enhancement of infection.'''(12)''' The EBV IL-10 monomer is shown <scene name='56/564053/Vil-10_w_receptor/1'>here</scene>, with the vIL-10 in light blue and the IL-10R1 receptor shown in dark blue | ||
References | References | ||
