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GDH can be measured in a medical laboratory to evaluate the liver function. Elevated blood serum GDH levels indicate liver damage and GDH plays an important role in the differential diagnosis of liver disease, especially in combination with aminotransferases. GDH is localised in mitochondria, therefore practically none is liberated in generalised inflammatory diseases of the liver such as viral hepatitides. Liver diseases in which necrosis of hepatocytes is the predominant event, such as toxic liver damage or hypoxic liver disease, are characterised by high serum GDH levels. GDH is important for distinguishing between acute viral hepatitis and acute toxic liver necrosis or acute hypoxic liver disease, particularly in the case of liver damage with very high aminotransferases. In clinical trials, GDH can serve as a measurement for the safety of a drug.