Sandbox Reserved 761: Difference between revisions
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'''GTP:''' | '''GTP:''' | ||
*<scene name='56/564037/Gtp/1'>GTP</scene>is a potent inhibitor (red) for the reaction of GDH (yellow) that binds at the base of the antenna, wedged in between the NAD binding domain and the pivot helix. This binding site is only available for GTP binding when the catalytic cleft is closed. Therefore, after GTP binds to the 'closed' conformation it is more difficult for the 'mouth' to open and release either NAD+ and NADP+ as coenzyme <ref>D'Mello, J. P. F.. "Glutamate Dehydrogenase." Amino Acids in Human Nutrition and Health. 2012. 1-23. Print</ref>. | *<scene name='56/564037/Gtp/1'>GTP</scene> is a potent inhibitor (red) for the reaction of GDH (yellow) that binds at the base of the antenna, wedged in between the NAD binding domain and the pivot helix. This binding site is only available for GTP binding when the catalytic cleft is closed. Therefore, after GTP binds to the 'closed' conformation it is more difficult for the 'mouth' to open and release either NAD+ and NADP+ as coenzyme <ref>D'Mello, J. P. F.. "Glutamate Dehydrogenase." Amino Acids in Human Nutrition and Health. 2012. 1-23. Print</ref>. | ||
'''GDP:''' | '''GDP:''' | ||
