Sandbox Reserved 777: Difference between revisions
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== Protein Expression == | == Protein Expression == | ||
IL-10 is a broadly expressed cytokine, usually in response to a stimulus. The gene is located on chromosome 1 and encodes a 178 amino acid peptide. It is translated by cells of the adaptive immune system through a variety of T- and B-cells, as well as by the innate immune system through dendritic cells, natural killer cells, mast cells, macrophages, eosinophils and neutrophils.<ref>Saraiva M and O’Garra A. The regulation of IL-10 production by immune cells. Nature Reviews Immunology. 2010 Mar; 10:170-181</ref> The exact signaling pathway that leads to IL-10 expression in most immune cells is unclear; however, it is known that the extra-cellular signal regulated kinase (ERK) cascade is one pathway activated in macrophages and myeloid dendritic cells that does lead to IL-10 expression.<ref | IL-10 is a broadly expressed cytokine, usually in response to a stimulus. The gene is located on chromosome 1 and encodes a 178 amino acid peptide. It is translated by cells of the adaptive immune system through a variety of T- and B-cells, as well as by the innate immune system through dendritic cells, natural killer cells, mast cells, macrophages, eosinophils and neutrophils.<ref name="saraiva">Saraiva M and O’Garra A. The regulation of IL-10 production by immune cells. Nature Reviews Immunology. 2010 Mar; 10:170-181</ref> The exact signaling pathway that leads to IL-10 expression in most immune cells is unclear; however, it is known that the extra-cellular signal regulated kinase (ERK) cascade is one pathway activated in macrophages and myeloid dendritic cells that does lead to IL-10 expression.<ref name="saraiva" /> | ||
== Mechanism of Action == | == Mechanism of Action == | ||
