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== Introduction ==

Interleukin 10 (IL-10) belongs to a class of proteins called cytokines. Cytokines are chemical messengers that are produced by and act on cells of the immune system.<ref>National Institute of Allergy and Infectious Diseases, ”Immune Cells and their Products: Cytokines”. Web. 16Nov2013 <http://www.niaid.nih.gov/topics/immuneSystem/immuneCells/Pages/cytokines.aspx></ref> It is also part of the IL-10 family of cytokines, which also includes IL-19, IL-20, IL-22, IL-24 and IL-26. This grouping was made based on similarities in structure, function, and location of the encoding genes.<ref name="sabat">Sabat, Robert. IL-10 family of cytokines. Cytokine Growth Factor Rev. 2010; 21:315–324</ref> IL-10 has also previously been called cytokine synthesis inhibitory factor (CSIF) because of its anti-inflammatory properties and ability to inhibit the production of other cytokines.<ref name="dewaal">de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries, JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 1991 Nov; 174(5):1209-1220</ref> The ability to limit the immune response to pathogens is crucial to preventing self-inflicted damage to the host. This cytokine is expressed in many eukaryotic hosts, as well as some viruses. A quick protein BLAST of the human IL-10 sequence reveals homology with IL-10 of many other primate species, as well as that found in bats, horses, elephants, rodents, sheep, cats and birds. The remainder of this page will focus on human IL-10.

Interleukin 10 (IL-10) belongs to a class of proteins called cytokines. Cytokines are chemical messengers that are produced by and act on cells of the immune system.<ref>National Institute of Allergy and Infectious Diseases, ”Immune Cells and their Products: Cytokines”. Web. 16Nov2013 <http://www.niaid.nih.gov/topics/immuneSystem/immuneCells/Pages/cytokines.aspx></ref> It is also part of the IL-10 family of cytokines, which also includes IL-19, IL-20, IL-22, IL-24 and IL-26. This grouping was made based on similarities in structure, function, and location of the encoding genes.<ref name="sabat">Sabat, Robert. IL-10 family of cytokines. Cytokine Growth Factor Rev. 2010; 21:315–324</ref> IL-10 has also previously been called cytokine synthesis inhibitory factor (CSIF) because of its anti-inflammatory properties and ability to inhibit the production of other cytokines.<ref name="dewaal">de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries, JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 1991 Nov; 174(5):1209-1220</ref> The ability to limit the immune response to pathogens is crucial to preventing self-inflicted damage to the host. This cytokine is expressed in many eukaryotic hosts, as well as some viruses. A quick protein BLAST<ref>Basic Local Alignment Search Tool (BLAST), http://blast.ncbi.nlm.nih.gov/Blast.cgi</ref> of the human IL-10 sequence reveals homology with IL-10 of many other primate species, as well as that found in bats, horses, elephants, rodents, sheep, cats and birds. The remainder of this page will focus on human IL-10.

== Structure ==

Sandbox Reserved 777: Difference between revisions

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 == Introduction ==
 <Structure load='2H24' size='300' frame='true' align='right' caption='The interleukin 10 monomer. PDB 2H24' scene='Insert optional scene name here' />
-Interleukin 10 (IL-10) belongs to a class of proteins called cytokines. Cytokines are chemical messengers that are produced by and act on cells of the immune system.<ref>National Institute of Allergy and Infectious Diseases, ”Immune Cells and their Products: Cytokines”. Web. 16Nov2013 <http://www.niaid.nih.gov/topics/immuneSystem/immuneCells/Pages/cytokines.aspx></ref>   It is also part of the IL-10 family of cytokines, which also includes IL-19, IL-20, IL-22, IL-24 and IL-26.  This grouping was made based on similarities in structure, function, and location of the encoding genes.<ref name="sabat">Sabat, Robert. IL-10 family of cytokines.  Cytokine Growth Factor Rev. 2010; 21:315–324</ref>  IL-10 has also previously been called cytokine synthesis inhibitory factor (CSIF) because of its anti-inflammatory properties and ability to inhibit the production of other cytokines.<ref name="dewaal">de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries, JE.  Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 1991 Nov; 174(5):1209-1220</ref>  The ability to limit the immune response to pathogens is crucial to preventing self-inflicted damage to the host. This cytokine is expressed in many eukaryotic hosts, as well as some viruses. A quick protein BLAST of the human IL-10 sequence reveals homology with IL-10 of many other primate species, as well as that found in bats, horses, elephants, rodents, sheep, cats and birds.  The remainder of this page will focus on human IL-10.
+Interleukin 10 (IL-10) belongs to a class of proteins called cytokines. Cytokines are chemical messengers that are produced by and act on cells of the immune system.<ref>National Institute of Allergy and Infectious Diseases, ”Immune Cells and their Products: Cytokines”. Web. 16Nov2013 <http://www.niaid.nih.gov/topics/immuneSystem/immuneCells/Pages/cytokines.aspx></ref>   It is also part of the IL-10 family of cytokines, which also includes IL-19, IL-20, IL-22, IL-24 and IL-26.  This grouping was made based on similarities in structure, function, and location of the encoding genes.<ref name="sabat">Sabat, Robert. IL-10 family of cytokines.  Cytokine Growth Factor Rev. 2010; 21:315–324</ref>  IL-10 has also previously been called cytokine synthesis inhibitory factor (CSIF) because of its anti-inflammatory properties and ability to inhibit the production of other cytokines.<ref name="dewaal">de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries, JE.  Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 1991 Nov; 174(5):1209-1220</ref>  The ability to limit the immune response to pathogens is crucial to preventing self-inflicted damage to the host. This cytokine is expressed in many eukaryotic hosts, as well as some viruses. A quick protein BLAST<ref>Basic Local Alignment Search Tool (BLAST), http://blast.ncbi.nlm.nih.gov/Blast.cgi</ref> of the human IL-10 sequence reveals homology with IL-10 of many other primate species, as well as that found in bats, horses, elephants, rodents, sheep, cats and birds.  The remainder of this page will focus on human IL-10.
 == Structure ==