Sandbox Reserved 769: Difference between revisions
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==Enzyme Structure== | ==Enzyme Structure== | ||
Tryptophan synthase typically exists as an α-ββ-α complex. | |||
'''Hydrophobic channel:''' The α and β active sites are separated by a 30 Å long hydrophobic channel contained within the enzyme allowing for the diffusion of indole. If the channel did not exist, the indole formed at an α active site would quickly diffuse away and be lost to the cell as it is hydrophobic and can easily cross membranes. As such, the channel is essential for enzyme complex function<ref name="cite6">http://www.annualreviews.org/doi/abs/10.1146/annurev.biochem.70.1.149</ref> | '''Hydrophobic channel:''' The α and β active sites are separated by a 30 Å long hydrophobic channel contained within the enzyme allowing for the diffusion of indole. If the channel did not exist, the indole formed at an α active site would quickly diffuse away and be lost to the cell as it is hydrophobic and can easily cross membranes. As such, the channel is essential for enzyme complex function<ref name="cite6">http://www.annualreviews.org/doi/abs/10.1146/annurev.biochem.70.1.149</ref> | ||
