Interleukin-1 beta: Difference between revisions

Line 25:

[[Image:Ternary complex paradigm.png||250px|right|]]

<scene name='57/571319/Scene_3/1'> Interleukin-1 beta signal complex</scene> 3D structure was showed here, and the cartoon (right) showed the formation of the ternary complex paradigm,the primary receptors first bind their corresponding cytokine ligands and then engage the accessory receptor (which is incapable of binding cytokines by itself). The overall ternary architecture of the IL-1β–IL-1RI–IL-1RAcP signaling complex has the cytoplasmic TIR domain necessary for signal transduction. The IL-1RI-IL-1RAcP interface was most hydrogen-bonded and signal was transferred through the highly packed hydrophobic region between receptor accessory and IL-1R liganded with IL-1β[6]

<scene name='57/571319/Scene_3/1'> Interleukin-1 beta signal complex</scene> 3D structure was showed here, and the cartoon (right) showed the formation of the ternary complex paradigm,the primary receptors('''IL-1R''') first bind their corresponding cytokine ligands('''IL-1β''') and then engage the accessory receptor('''IL-1RAcP''') (which is incapable of binding cytokines by itself). The overall ternary architecture of the IL-1β–IL-1RI–IL-1RAcP signaling complex has the cytoplasmic TIR domain necessary for signal transduction. The IL-1RI-IL-1RAcP interface was most hydrogen-bonded and signal was transferred through the highly packed hydrophobic region between receptor accessory and IL-1R liganded with IL-1β[6]

The dimer complex with conserved area was showed when you <scene name='57/571319/Scene_3/2'>click here</scene>. The insert are ligands(IL-1β), which are present as conserved structure as well as green ribbon. The two IL-1Rs and two IL-1RAcPs are colored as purple and blue, respectively.

==Clinical significance==

Interleukin-1 beta: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 25: / Line 25: @@
 [[Image:Ternary complex paradigm.png||250px|right|]]
-<scene name='57/571319/Scene_3/1'> Interleukin-1 beta signal complex</scene> 3D structure was showed here, and the cartoon (right) showed the formation of the ternary complex paradigm,the primary receptors first bind their corresponding cytokine ligands and then engage the accessory receptor (which is incapable of binding cytokines by itself). The overall ternary architecture of the IL-1β–IL-1RI–IL-1RAcP signaling complex has the cytoplasmic TIR domain necessary for signal transduction. The IL-1RI-IL-1RAcP interface was most hydrogen-bonded and signal was transferred through the highly packed hydrophobic region between receptor accessory and IL-1R liganded with IL-1β[6]
+<scene name='57/571319/Scene_3/1'> Interleukin-1 beta signal complex</scene> 3D structure was showed here, and the cartoon (right) showed the formation of the ternary complex paradigm,the primary receptors('''IL-1R''') first bind their corresponding cytokine ligands('''IL-1β''') and then engage the accessory receptor('''IL-1RAcP''') (which is incapable of binding cytokines by itself). The overall ternary architecture of the IL-1β–IL-1RI–IL-1RAcP signaling complex has the cytoplasmic TIR domain necessary for signal transduction. The IL-1RI-IL-1RAcP interface was most hydrogen-bonded and signal was transferred through the highly packed hydrophobic region between receptor accessory and IL-1R liganded with IL-1β[6]
+The dimer complex with conserved area was showed when you <scene name='57/571319/Scene_3/2'>click here</scene>. The insert are ligands(IL-1β), which are present as conserved structure as well as green ribbon. The two IL-1Rs and  two IL-1RAcPs are colored as purple and blue, respectively.
 ==Clinical significance==