4mq2: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor===

~~The~~ entry ~~4mq2~~ is ~~ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[http://omim.org/entry/614104 614104]]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>

~~Authors~~: ~~Lukacs, C~~.M.~~, Janson, C.A~~., ~~Garvie, C., Liang, L~~.

==Function==

[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>

~~Description~~: ~~The crystal structure of DYRK1a with a bound pyrido~~[2,3-d]~~pyrimidine inhibitor~~

==About this Structure==

[[4mq2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQ2 OCA].

==Reference==

[[Category: Dual-specificity kinase]]

[[Category: Garvie, C.]]

[[Category: Janson, C A.]]

[[Category: Liang, L.]]

[[Category: Lukacs, C M.]]

[[Category: Dyrk1a]]

[[Category: Dyrk1b]]

[[Category: Kinase]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4mq2|  PDB=4mq2  |  SCENE=  }}
+===The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor===
+{{ABSTRACT_PUBMED_24239188}}
-The entry 4mq2 is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[http://omim.org/entry/614104 614104]]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>
-Authors: Lukacs, C.M., Janson, C.A., Garvie, C., Liang, L.
+==Function==
+[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>
-Description: The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor
+==About this Structure==
+[[4mq2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQ2 OCA].
+==Reference==
+<ref group="xtra">PMID:024239188</ref><references group="xtra"/><references/>
+[[Category: Dual-specificity kinase]]
+[[Category: Garvie, C.]]
+[[Category: Janson, C A.]]
+[[Category: Liang, L.]]
+[[Category: Lukacs, C M.]]
+[[Category: Dyrk1a]]
+[[Category: Dyrk1b]]
+[[Category: Kinase]]
+[[Category: Transferase-transferase inhibitor complex]]