4ixv: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)===

~~The entry 4ixv~~ is ~~ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.

~~Authors~~: ~~Cousido-Siah, A~~.~~, Mitschler, A~~.~~, Ruiz, F~~.~~X., Whitehouse, D., Beckett, P., Van Zandt, M.C., Ji, M.K., Ryder, T., Jagdmann, R., Andreoli, M., Olczak, J., Mazur, M., Czestkowski, W., Piotrowska, W., Schroeter, H., Golebiowski, A., Podjarny, A~~.

==About this Structure==

[[4ixv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXV OCA].

~~Description~~: ~~Crystal structure of human~~ Arginase-~~2 complexed with inhbitor 2d~~

==Reference==

[[Category: Arginase]]

[[Category: Andreoli, M.]]

[[Category: Beckett, P.]]

[[Category: Cousido-Siah, A.]]

[[Category: Czestkowski, W.]]

[[Category: Golebiowski, A.]]

[[Category: Jagdmann, R.]]

[[Category: Ji, M K.]]

[[Category: Mazur, M.]]

[[Category: Mitschler, A.]]

[[Category: Olczak, J.]]

[[Category: Piotrowska, W.]]

[[Category: Podjarny, A.]]

[[Category: Ruiz, F X.]]

[[Category: Ryder, T.]]

[[Category: Schroeter, H.]]

[[Category: Whitehouse, D.]]

[[Category: Zandt, M C.Van.]]

[[Category: Alpha/beta fold]]

[[Category: Arginine metabolism]]

[[Category: Hydrolase]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Metalloenzyme]]

[[Category: Mitochondrion]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4ixv|  PDB=4ixv  |  SCENE=  }}
+===Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)===
+{{ABSTRACT_PUBMED_23886684}}
-The entry 4ixv is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
-Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D., Beckett, P., Van Zandt, M.C., Ji, M.K., Ryder, T., Jagdmann, R., Andreoli, M., Olczak, J., Mazur, M., Czestkowski, W., Piotrowska, W., Schroeter, H., Golebiowski, A., Podjarny, A.
+==About this Structure==
+[[4ixv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXV OCA].
-Description: Crystal structure of human Arginase-2 complexed with inhbitor 2d
+==Reference==
+<ref group="xtra">PMID:023886684</ref><references group="xtra"/><references/>
+[[Category: Arginase]]
+[[Category: Andreoli, M.]]
+[[Category: Beckett, P.]]
+[[Category: Cousido-Siah, A.]]
+[[Category: Czestkowski, W.]]
+[[Category: Golebiowski, A.]]
+[[Category: Jagdmann, R.]]
+[[Category: Ji, M K.]]
+[[Category: Mazur, M.]]
+[[Category: Mitschler, A.]]
+[[Category: Olczak, J.]]
+[[Category: Piotrowska, W.]]
+[[Category: Podjarny, A.]]
+[[Category: Ruiz, F X.]]
+[[Category: Ryder, T.]]
+[[Category: Schroeter, H.]]
+[[Category: Whitehouse, D.]]
+[[Category: Zandt, M C.Van.]]
+[[Category: Alpha/beta fold]]
+[[Category: Arginine metabolism]]
+[[Category: Hydrolase]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Metalloenzyme]]
+[[Category: Mitochondrion]]