4iku: Difference between revisions
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{{STRUCTURE_4iku| PDB=4iku | SCENE= }} | |||
===Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide=== | |||
{{ABSTRACT_PUBMED_23767698}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/AMPM1_HUMAN AMPM1_HUMAN]] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.<ref>PMID:16274222</ref> <ref>PMID:17114291</ref> | |||
==About this Structure== | |||
[[4iku]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKU OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023767698</ref><references group="xtra"/><references/> | |||
[[Category: Methionyl aminopeptidase]] | |||
[[Category: Addlagatta, A.]] | |||
[[Category: Arya, T.]] | |||
[[Category: Kishor, C.]] | |||
[[Category: Aminopeptidase]] | |||
[[Category: Hydrolase]] | |||
[[Category: Pita-bread fold]] | |||
[[Category: Ribosome]] | |||
Revision as of 13:39, 11 December 2013
Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide
Template:ABSTRACT PUBMED 23767698
Function
[AMPM1_HUMAN] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.[1] [2]
About this Structure
4iku is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Kishor C, Arya T, Reddi R, Chen X, Saddanapu V, Marapaka AK, Gumpena R, Ma D, Liu JO, Addlagatta A. Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases. J Med Chem. 2013 Jun 27. PMID:23767698 doi:https://dx.doi.org/10.1021/jm400395p
- ↑ Addlagatta A, Hu X, Liu JO, Matthews BW. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 2005 Nov 15;44(45):14741-9. PMID:16274222 doi:10.1021/bi051691k
- ↑ Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17. PMID:17114291
