4nkh: Difference between revisions
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{{STRUCTURE_4nkh| PDB=4nkh | SCENE= }} | |||
===Crystal structure of SspH1 LRR domain=== | |||
{{ABSTRACT_PUBMED_24248594}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SSPH1_SALT1 SSPH1_SALT1]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host PKN1. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression, probably via interaction with PKN1.<ref>PMID:10564523</ref> <ref>PMID:12819095</ref> <ref>PMID:16611232</ref> <ref>PMID:18005683</ref> | |||
==About this Structure== | |||
[[4nkh]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKH OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024248594</ref><references group="xtra"/><references/> | |||
[[Category: Keszei, A F.A.]] | |||
[[Category: Mccormick, C.]] | |||
[[Category: Rohde, J R.]] | |||
[[Category: Sicheri, F.]] | |||
[[Category: Tyers, M.]] | |||
[[Category: Xiaojing, T.]] | |||
[[Category: Zeqiraj, E.]] | |||
[[Category: E3 ligase substrate interaction domain]] | |||
[[Category: Leucine-rich repeat]] | |||
[[Category: Ligase]] | |||