4cgz: Difference between revisions

Line 1:

~~'''Unreleased~~ structure'''

===Crystal structure of the Bloom's syndrome helicase BLM in complex with DNA===

The entry ~~4cgz is ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Bloom syndrome. The disease is caused by mutations affecting the gene represented in this entry.

~~Authors~~: ~~Newman, J~~.A.~~, Savitsky, P~~.~~, Krojer, T~~.~~, von Delft, F~~.~~, Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O~~.

==Function==

[[http://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).<ref>PMID:9388193</ref> <ref>PMID:12019152</ref> <ref>PMID:21325134</ref> <ref>PMID:23509288</ref>

~~Description~~: ~~Crystal structure of the Bloom's syndrome~~ helicase ~~BLM in~~ complex ~~with DNA~~

==About this Structure==

[[4cgz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CGZ OCA].

==Reference==

[[Category: DNA helicase]]

[[Category: Arrowsmith, C H.]]

[[Category: Bountra, C.]]

[[Category: Delft, F von.]]

[[Category: Edwards, A.]]

[[Category: Gileadi, O.]]

[[Category: Krojer, T.]]

[[Category: Newman, J A.]]

[[Category: Savitsky, P.]]

[[Category: Hydrolase-dna complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4cgz|  PDB=4cgz  |  SCENE=  }}
+===Crystal structure of the Bloom's syndrome helicase BLM in complex with DNA===
-The entry 4cgz is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Bloom syndrome. The disease is caused by mutations affecting the gene represented in this entry.
-Authors: Newman, J.A., Savitsky, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
+==Function==
+[[http://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).<ref>PMID:9388193</ref> <ref>PMID:12019152</ref> <ref>PMID:21325134</ref> <ref>PMID:23509288</ref>
-Description: Crystal structure of the Bloom's syndrome helicase BLM in complex with DNA
+==About this Structure==
+[[4cgz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CGZ OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: DNA helicase]]
+[[Category: Arrowsmith, C H.]]
+[[Category: Bountra, C.]]
+[[Category: Delft, F von.]]
+[[Category: Edwards, A.]]
+[[Category: Gileadi, O.]]
+[[Category: Krojer, T.]]
+[[Category: Newman, J A.]]
+[[Category: Savitsky, P.]]
+[[Category: Hydrolase-dna complex]]