4m7f: Difference between revisions
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{{STRUCTURE_4m7f| PDB=4m7f | SCENE= }} | |||
===Crystal structure of tetrameric fibrinogen-like recognition domain of FIBCD1 with bound ManNAc=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FBCD1_HUMAN FBCD1_HUMAN]] Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.<ref>PMID:19710473</ref> <ref>PMID:19892701</ref> | |||
==About this Structure== | |||
[[4m7f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7F OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Greenhough, T J.]] | |||
[[Category: Holmskov, U.]] | |||
[[Category: Shrive, A K.]] | |||
[[Category: Fibrinogen-like domain]] | |||
[[Category: N-acetyl-binding protein]] | |||
[[Category: Sugar binding protein]] | |||
Revision as of 13:50, 11 December 2013
Crystal structure of tetrameric fibrinogen-like recognition domain of FIBCD1 with bound ManNAc
Function
[FBCD1_HUMAN] Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.[1] [2]
About this Structure
4m7f is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Schlosser A, Thomsen T, Moeller JB, Nielsen O, Tornoe I, Mollenhauer J, Moestrup SK, Holmskov U. Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin. J Immunol. 2009 Sep 15;183(6):3800-9. doi: 10.4049/jimmunol.0901526. Epub 2009, Aug 26. PMID:19710473 doi:https://dx.doi.org/10.4049/jimmunol.0901526
- ↑ Thomsen T, Moeller JB, Schlosser A, Sorensen GL, Moestrup SK, Palaniyar N, Wallis R, Mollenhauer J, Holmskov U. The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. J Biol Chem. 2010 Jan 8;285(2):1229-38. doi: 10.1074/jbc.M109.061523. Epub 2009, Nov 5. PMID:19892701 doi:https://dx.doi.org/10.1074/jbc.M109.061523
