Pseudoenzyme: Difference between revisions
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== Pseudoenzyme == | == Pseudoenzyme == | ||
[[Pseudoenzyme|pseudoenzymes]] are proteins that cannot catalyze chemical reactions despite being clearly related structurally to functioning enzymes. Many enzyme families contain inactive members. For example, a number of human kinases lack at least one of the key amino acids necessary for catalysis of phosphate transfer. Often [[Pseudoenzyme|pseudoenzymes]] still have biological roles, albeit non-catalytic. Some assist true enzymes in obtaining functional folds, some server as platforms for other proteins to interact, and some are escorts for proteins <ref>PMID: 23559232</ref><ref>PMID: 23559233</ref>. | |||
==3D structures of Pseudoenzymes== | ==3D structures of Pseudoenzymes== | ||
* C-terminal domain of splicing factor Prp8p | * C-terminal domain of splicing factor Prp8p ([[2og4]]) resembles an isopeptidase converted to a platform | ||
* the structure of a fragment of integrin-like kinase ([[GET PDB ID]]) demonstrated it is not a kinase and instead serves a structural role linking the cell's cytoskeleton to surface receptors GET PDB ID BY LOOKING UP | |||
==References== | ==References== | ||
<references/> | <references/> | ||
==Related== | |||
* [[GET PDB ID by LOOKING UP CASK and Konark Mukherjee -- may be a 2008 Cell paper, hard to tell from citation if same]] - CASK was originally thought to be a [Pseudoenzyme|pseudoenzyme]], but after the structural was solved it was apparent it could use alternative amino acids in the kinase reaction | |||
[[Category:Pseudoenzyme]] | [[Category:Pseudoenzyme]] | ||
