2srt: Difference between revisions
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New page: left|200px<br /> <applet load="2srt" size="450" color="white" frame="true" align="right" spinBox="true" caption="2srt" /> '''CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 AT ... |
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[[Image:2srt.gif|left|200px]]<br /> | [[Image:2srt.gif|left|200px]]<br /><applet load="2srt" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2srt" size=" | |||
caption="2srt" /> | caption="2srt" /> | ||
'''CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 AT PH 5.5 AND 40OC COMPLEXED WITH INHIBITOR'''<br /> | '''CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 AT PH 5.5 AND 40OC COMPLEXED WITH INHIBITOR'''<br /> | ||
==Overview== | ==Overview== | ||
The three-dimensional structure of the catalytic domain of stromelysin-1 | The three-dimensional structure of the catalytic domain of stromelysin-1 complexed with an N-carboxyl alkyl inhibitor has been determined by NMR methods. The global fold consists of three helices, a five stranded beta-sheet and a methionine located in a turn near the catalytic histidines, classifying stromelysin-1 as a metzincin. Stromelysin-1 is unique in having two independent zinc binding sites: a catalytic site and a structural site. The inhibitor binds in an extended conformation. The S1' subsite is a deep hydrophobic pocket, whereas S2' appears shallow and S3' open. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
2SRT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and INH as [http://en.wikipedia.org/wiki/ligands ligands]. This structure | 2SRT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=INH:'>INH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure supersedes the now removed PDB entry 1SRT. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SRT OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Stromelysin 1]] | [[Category: Stromelysin 1]] | ||
[[Category: Connell, J | [[Category: Connell, J F.O.]] | ||
[[Category: Gooley, P | [[Category: Gooley, P R.]] | ||
[[Category: INH]] | [[Category: INH]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: metzincin]] | [[Category: metzincin]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:49:26 2008'' | ||
