4ifh: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4ifh|  PDB=4ifh  |  SCENE=  }}
===Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619===


The entry 4ifh is ON HOLD
==Function==
[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> 


Authors: Liang, W.G., Guo, Q., Deprez, R., Deprez, B., Tang, W.
==About this Structure==
[[4ifh]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4gse 4gse]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IFH OCA].  


Description: Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619
==Reference==
<references group="xtra"/><references/>
[[Category: Insulysin]]
[[Category: Deprez, B.]]
[[Category: Deprez, R.]]
[[Category: Guo, Q.]]
[[Category: Liang, W G.]]
[[Category: Tang, W.]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Insulin degrading enzyme]]
Retrieved from "https://proteopedia.org/4ifh"