4nab: Difference between revisions
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{{STRUCTURE_4nab| PDB=4nab | SCENE= }} | |||
===Structure of the (SR)Ca2+-ATPase mutant E309Q in the Ca2-E1-MgAMPPCP form=== | |||
{{ABSTRACT_PUBMED_24270570}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT]] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity). | |||
==About this Structure== | |||
[[4nab]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAB OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024270570</ref><references group="xtra"/><references/> | |||
[[Category: Calcium-transporting ATPase]] | |||
[[Category: Andersen, J P.]] | |||
[[Category: Arnou, B.]] | |||
[[Category: Bublitz, M.]] | |||
[[Category: Clausen, J D.]] | |||
[[Category: Jaxel, C.]] | |||
[[Category: Maire, M le.]] | |||
[[Category: Montigny, C.]] | |||
[[Category: Mueller, J V.]] | |||
[[Category: Nissen, P.]] | |||
[[Category: Calcium-transporting atpase]] | |||
[[Category: Hydrolase]] | |||
[[Category: Mutant e309q]] | |||
[[Category: P-type atpase]] | |||
[[Category: Sarcoplasmic reticulum]] | |||
Revision as of 10:27, 18 December 2013
Structure of the (SR)Ca2+-ATPase mutant E309Q in the Ca2-E1-MgAMPPCP form
Template:ABSTRACT PUBMED 24270570
Function
[AT2A1_RABIT] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).
About this Structure
4nab is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Clausen JD, Bublitz M, Arnou B, Montigny C, Jaxel C, Moller JV, Nissen P, Andersen JP, le Maire M. SERCA mutant E309Q binds two Ca(2+) ions but adopts a catalytically incompetent conformation. EMBO J. 2013 Dec 11;32(24):3231-43. doi: 10.1038/emboj.2013.250. Epub 2013 Nov, 22. PMID:24270570 doi:https://dx.doi.org/10.1038/emboj.2013.250
