4lr2: Difference between revisions
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{{STRUCTURE_4lr2| PDB=4lr2 | SCENE= }} | |||
===Crystal Structure of Human ENPP4 (apo)=== | |||
{{ABSTRACT_PUBMED_22995898}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ENPP4_HUMAN ENPP4_HUMAN]] Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.<ref>PMID:22995898</ref> | |||
==About this Structure== | |||
[[4lr2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LR2 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:022995898</ref><references group="xtra"/><references/> | |||
[[Category: Albright, R A.]] | |||
[[Category: Braddock, D T.]] | |||
[[Category: Enpp4]] | |||
[[Category: Hydrolase]] | |||
[[Category: Npp4]] | |||
[[Category: Phosphodiesterase]] | |||
Revision as of 10:29, 18 December 2013
Crystal Structure of Human ENPP4 (apo)
Template:ABSTRACT PUBMED 22995898
Function
[ENPP4_HUMAN] Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.[1]
About this Structure
4lr2 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM, Braddock DT. NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood. 2012 Nov 22;120(22):4432-40. doi: 10.1182/blood-2012-04-425215. Epub 2012 , Sep 20. PMID:22995898 doi:https://dx.doi.org/10.1182/blood-2012-04-425215
- ↑ Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM, Braddock DT. NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood. 2012 Nov 22;120(22):4432-40. doi: 10.1182/blood-2012-04-425215. Epub 2012 , Sep 20. PMID:22995898 doi:https://dx.doi.org/10.1182/blood-2012-04-425215
