4i2x: Difference between revisions
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{{STRUCTURE_4i2x| PDB=4i2x | SCENE= }} | |||
===Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SIRPG_HUMAN SIRPG_HUMAN]] Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.<ref>PMID:15383453</ref> | |||
==About this Structure== | |||
[[4i2x]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I2X OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Nettleship, J E.]] | |||
[[Category: OPPF, Oxford Protein Production Facility.]] | |||
[[Category: Owens, R J.]] | |||
[[Category: Ren, J.]] | |||
[[Category: Stuart, D I.]] | |||
[[Category: Cd47]] | |||
[[Category: Cell surface]] | |||
[[Category: Immune system]] | |||
[[Category: Oppf]] | |||
[[Category: Oxford protein production facility]] | |||
[[Category: Protein-fab complex]] | |||
[[Category: Signal regulatory protein]] | |||
[[Category: Structural genomic]] | |||
Revision as of 10:35, 18 December 2013
Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117
Function
[SIRPG_HUMAN] Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.[1]
About this Structure
4i2x is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Piccio L, Vermi W, Boles KS, Fuchs A, Strader CA, Facchetti F, Cella M, Colonna M. Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. Blood. 2005 Mar 15;105(6):2421-7. Epub 2004 Sep 21. PMID:15383453 doi:10.1182/blood-2004-07-2823
