4ndf: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Human Aprataxin (Aptx) bound to RNA-DNA, AMP, and Zn - product complex===

~~The~~ entry ~~4ndf~~ is ~~ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/APTX_HUMAN APTX_HUMAN]] Defects in APTX are the cause of ataxia-oculomotor apraxia syndrome (AOA) [MIM:[http://omim.org/entry/208920 208920]]. AOA is an autosomal recessive syndrome characterized by early-onset cerebellar ataxia, oculomotor apraxia, early areflexia and late peripheral neuropathy.<ref>PMID:11586299</ref> <ref>PMID:11586300</ref> <ref>PMID:12196655</ref> <ref>PMID:12629250</ref> <ref>PMID:14506070</ref> <ref>PMID:15852392</ref> <ref>PMID:15699391</ref>

~~Authors~~: ~~Schellenberg, M~~.J., ~~Tumbale~~, P.S., ~~Williams, R.S~~.

==Function==

[[http://www.uniprot.org/uniprot/APTX_HUMAN APTX_HUMAN]] DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.<ref>PMID:14755728</ref> <ref>PMID:15044383</ref> <ref>PMID:16547001</ref> <ref>PMID:16964241</ref> <ref>PMID:17276982</ref>

~~Description~~: ~~Human Aprataxin (Aptx) bound to RNA~~-~~DNA~~, ~~AMP~~, ~~and Zn~~ -~~product~~ complex

==About this Structure==

[[4ndf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NDF OCA].

==Reference==

[[Category: Schellenberg, M J.]]

[[Category: Tumbale, P S.]]

[[Category: Williams, R S.]]

[[Category: 5'-dna end processing]]

[[Category: 5'-dna end recognition]]

[[Category: Dna binding protein-rna-dna complex]]

[[Category: Dna repair]]

[[Category: Histidine triad domain]]

[[Category: Hit domain]]

[[Category: Protein-dna complex]]

[[Category: Zinc finger]]

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-'''Unreleased structure'''
+{{STRUCTURE_4ndf|  PDB=4ndf  |  SCENE=  }}
+===Human Aprataxin (Aptx) bound to RNA-DNA, AMP, and Zn - product complex===
-The entry 4ndf is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/APTX_HUMAN APTX_HUMAN]] Defects in APTX are the cause of ataxia-oculomotor apraxia syndrome (AOA) [MIM:[http://omim.org/entry/208920 208920]]. AOA is an autosomal recessive syndrome characterized by early-onset cerebellar ataxia, oculomotor apraxia, early areflexia and late peripheral neuropathy.<ref>PMID:11586299</ref> <ref>PMID:11586300</ref> <ref>PMID:12196655</ref> <ref>PMID:12629250</ref> <ref>PMID:14506070</ref> <ref>PMID:15852392</ref> <ref>PMID:15699391</ref>
-Authors: Schellenberg, M.J., Tumbale, P.S., Williams, R.S.
+==Function==
+[[http://www.uniprot.org/uniprot/APTX_HUMAN APTX_HUMAN]] DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.<ref>PMID:14755728</ref> <ref>PMID:15044383</ref> <ref>PMID:16547001</ref> <ref>PMID:16964241</ref> <ref>PMID:17276982</ref>
-Description: Human Aprataxin (Aptx) bound to RNA-DNA, AMP, and Zn -product complex
+==About this Structure==
+[[4ndf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NDF OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Schellenberg, M J.]]
+[[Category: Tumbale, P S.]]
+[[Category: Williams, R S.]]
+[[Category: 5'-dna end processing]]
+[[Category: 5'-dna end recognition]]
+[[Category: Dna binding protein-rna-dna complex]]
+[[Category: Dna repair]]
+[[Category: Histidine triad domain]]
+[[Category: Hit domain]]
+[[Category: Protein-dna complex]]
+[[Category: Zinc finger]]