4nqm: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand===

~~The entry 4nqm~~ is ~~ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

~~Authors~~: ~~Filippakopoulos, P~~.~~, Picaud, S~~.~~, Felletar, I., Martin, S., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium~~ (~~SGC~~)

==Function==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

~~Description: Crystal~~ Structure ~~of the first bromodomain of human BRD4 in complex with~~ a ~~triazolo~~-~~phthalazine ligand~~

==About this Structure==

[[4nqm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQM OCA].

==Reference==

[[Category: Arrowsmith, C H.]]

[[Category: Bountra, C.]]

[[Category: Delft, F von.]]

[[Category: Edwards, A M.]]

[[Category: Fedorov, O.]]

[[Category: Felletar, I.]]

[[Category: Filippakopoulos, P.]]

[[Category: Knapp, S.]]

[[Category: Martin, S.]]

[[Category: Picaud, S.]]

[[Category: SGC, Structural Genomics Consortium.]]

[[Category: Bromodomain]]

[[Category: Inhibition]]

[[Category: Sgc]]

[[Category: Small molecule inhibitor]]

[[Category: Structural genomics consortium]]

[[Category: Transcription]]

[[Category: Transcription-inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nqm|  PDB=4nqm  |  SCENE=  }}
+===Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand===
-The entry 4nqm is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
-Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Martin, S., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
+==Function==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand
+==About this Structure==
+[[4nqm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQM OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Arrowsmith, C H.]]
+[[Category: Bountra, C.]]
+[[Category: Delft, F von.]]
+[[Category: Edwards, A M.]]
+[[Category: Fedorov, O.]]
+[[Category: Felletar, I.]]
+[[Category: Filippakopoulos, P.]]
+[[Category: Knapp, S.]]
+[[Category: Martin, S.]]
+[[Category: Picaud, S.]]
+[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Bromodomain]]
+[[Category: Inhibition]]
+[[Category: Sgc]]
+[[Category: Small molecule inhibitor]]
+[[Category: Structural genomics consortium]]
+[[Category: Transcription]]
+[[Category: Transcription-inhibitor complex]]