Sandbox Reserved 829: Difference between revisions
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== '''Structure of PDX-1 homeodomain''' == | == '''Structure of PDX-1 homeodomain''' == <ref>doi : 10567702</ref> | ||
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Diabete is a metabolic disorder characterized by a hyperglycemia resulting from defects in insulin secretion or insulin action in function of the type of the diabetes (type I or II). <ref>PMID : 11834421</ref> | Diabete is a metabolic disorder characterized by a hyperglycemia resulting from defects in insulin secretion or insulin action in function of the type of the diabetes (type I or II). <ref>PMID : 11834421</ref> | ||
Five different proteins with functional defects, cause a form of diabetes termed MODY ( included in type II diabetes). Those include the enzyme GK and four transcription factors, including PDX-1 (MODY-4). | Five different proteins with functional defects, cause a form of diabetes termed MODY ( included in type II diabetes). Those include the enzyme GK and four transcription factors, including PDX-1 (MODY-4).<ref>PMID : 16092045</ref> | ||
Mutations of PDX-1 have also effects on the development of the pancreas and on the function of insulin-secreting cells. | Mutations of PDX-1 have also effects on the development of the pancreas and on the function of insulin-secreting cells. | ||
It could also be a pharmacological target for beta-cell defects in Type II diabetes, since it has a role as regulator of islet of Langerhans stem cell activity. | It could also be a pharmacological target for beta-cell defects in Type II diabetes, since it has a role as regulator of islet of Langerhans stem cell activity. | ||
== '''External Ressources ''' == | |||
!!!! METTRE LE LIEN !!!!! | |||
http://atlasgeneticsoncology.org/Genes/PDX1ID43921ch13q12.html | |||
(tres descriptif) | |||
http://diabetes.diabetesjournals.org/content/51/suppl_3/S320.long | |||
(regulation gene) | |||
== References == | == '''References''' == | ||
<references/> | <references/> | ||
=='''Protreopedia Page Contributors and Editors'''== | |||
Mégane DENU and Claire HUBRECHT | |||
Student 1A ESBS (Promo 2016) | |||
