Sandbox Reserved 821: Difference between revisions

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= Human C-reactive protein (CRP) =
= Human C-reactive protein (CRP) =


The C-reactive protein (CRP) is a plasma protein, mainly synthesized by the liver. Its concentration may increase rapidly,
The C-reactive protein (CRP) is a plasma protein, mainly synthesized by the liver. Its concentration may increase rapidly, as much as 1000-fold or more, in response to tissue injury, infection and inflammation: It's an acute-phase protein.
as much as 1000-fold or more, in response to tissue injury, infection and inflammation: It's an acute-phase protein.
 
This important rise in amount after inflammatory stimulus suggests that CRP is a part of the innate immune response in the host defense.
CRP binds to phosphocholine which is exposed on died or dying cells and expressed on the surfaces of pathogens, and then may activate the complement system via interaction with C1q, and enhance phagocytosis by macrophages via its binding to Fcγ receptors.In addition to the fact that this protein has been highly conserved during evolution, this suggests that CRP is a very important part of the innate immune response, in the host defense.
CRP is a pattern recognition molecule, binding to specific molecular configurations that are typically exposed during cell death or found on the surfaces of pathogens.
 
CRp belong to the pentraxin family.




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