Sandbox Reserved 821: Difference between revisions
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CRP binds to phosphocholine which is exposed on died or dying cells and expressed on the surfaces of pathogens. Then, it may activate the complement system via interaction with C1q, and enhance phagocytosis by macrophages via its binding to Fcγ receptors. In addition to the fact that this protein has been highly conserved during evolution, this suggests that CRP is a very important part of the innate immune response, in the host defense. | CRP binds to phosphocholine which is exposed on died or dying cells and expressed on the surfaces of pathogens. Then, it may activate the complement system via interaction with C1q, and enhance phagocytosis by macrophages via its binding to Fcγ receptors. In addition to the fact that this protein has been highly conserved during evolution, this suggests that CRP is a very important part of the innate immune response, in the host defense. | ||
This feature of amount increasing is curently used as a marker of inflammation in patients. | |||
CRP belong to the pentraxin family. | CRP belong to the pentraxin family. | ||
