4m4x: Difference between revisions
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===Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor (AHR) PAS-A Domain=== | ===Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor (AHR) PAS-A Domain=== | ||
{{ABSTRACT_PUBMED_24001774}} | {{ABSTRACT_PUBMED_24001774}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/AHR_MOUSE AHR_MOUSE]] Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.<ref>PMID:1314586</ref> <ref>PMID:7961644</ref> <ref>PMID:7969080</ref> <ref>PMID:8806883</ref> <ref>PMID:9427285</ref> <ref>PMID:10973493</ref> <ref>PMID:10639156</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4m4x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4m4x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4X OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024001774</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024001774</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Kim, Y.]] | [[Category: Kim, Y.]] | ||
[[Category: Potluri, N.]] | [[Category: Potluri, N.]] | ||
