4nz8: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of porcine aminopeptidase-N complexed with cleaved poly-alanine===

~~The entry 4nz8~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/AMPN_PIG AMPN_PIG]] Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines and involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis (By similarity). It is able to degrade Leu-enkephalin and Met-enkephalin but not cholecystokinin CCK8, neuromedin C (GRP-10), somatostatin-14, substance P and vasoactive intestinal peptide. In case of porcine transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCoV) infections, serves as a receptor for TGEV and PRCoV spike glycoprotein in a species-specific manner.<ref>PMID:7913510</ref> <ref>PMID:1350661</ref> <ref>PMID:7911642</ref> <ref>PMID:8985407</ref> <ref>PMID:9634079</ref>

~~Authors~~: ~~Chen, L~~.~~, Lin, Y~~.L.~~, Peng, G~~.~~, Li, F~~.

==About this Structure==

[[4nz8]] is a 3 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4h5h 4h5h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZ8 OCA].

~~Description~~: ~~Crystal structure of porcine~~ aminopeptidase~~-N complexed with cleaved poly-alanine~~

==Reference==

[[Category: Membrane alanyl aminopeptidase]]

[[Category: Chen, L.]]

[[Category: Li, F.]]

[[Category: Lin, Y L.]]

[[Category: Peng, G.]]

[[Category: Hydrolase]]

[[Category: Zinc aminopeptidase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nz8|  PDB=4nz8  |  SCENE=  }}
+===Crystal structure of porcine aminopeptidase-N complexed with cleaved poly-alanine===
+{{ABSTRACT_PUBMED_23071329}}
-The entry 4nz8 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/AMPN_PIG AMPN_PIG]] Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines and involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis (By similarity). It is able to degrade Leu-enkephalin and Met-enkephalin but not cholecystokinin CCK8, neuromedin C (GRP-10), somatostatin-14, substance P and vasoactive intestinal peptide. In case of porcine transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCoV) infections, serves as a receptor for TGEV and PRCoV spike glycoprotein in a species-specific manner.<ref>PMID:7913510</ref> <ref>PMID:1350661</ref> <ref>PMID:7911642</ref> <ref>PMID:8985407</ref> <ref>PMID:9634079</ref>
-Authors: Chen, L., Lin, Y.L., Peng, G., Li, F.
+==About this Structure==
+[[4nz8]] is a 3 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4h5h 4h5h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZ8 OCA].
-Description: Crystal structure of porcine aminopeptidase-N complexed with cleaved poly-alanine
+==Reference==
+<ref group="xtra">PMID:023071329</ref><references group="xtra"/><references/>
+[[Category: Membrane alanyl aminopeptidase]]
+[[Category: Chen, L.]]
+[[Category: Li, F.]]
+[[Category: Lin, Y L.]]
+[[Category: Peng, G.]]
+[[Category: Hydrolase]]
+[[Category: Zinc aminopeptidase]]