4lts: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors===

~~The entry 4lts~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

~~Authors~~: Zheng, X., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynoids, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Oh, A., Wang, W., Zak, M., Wang, Y.~~, Yuen, P~~.~~, Bair, K~~.W.

==About this Structure==

[[4lts]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LTS OCA].

~~Description~~: ~~Discovery of Potent and Efficacious Cyanoguanidine~~-~~containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors~~

==Reference==

[[Category: Nicotinamide phosphoribosyltransferase]]

[[Category: Bair, K W.]]

[[Category: Baumeister, T.]]

[[Category: Buckmelter, A J.]]

[[Category: Caligiuri, M.]]

[[Category: Clodfelter, K H.]]

[[Category: Dragovich, P S.]]

[[Category: Han, B.]]

[[Category: Ho, Y.]]

[[Category: Kley, N.]]

[[Category: Lin, J.]]

[[Category: Oh, A.]]

[[Category: Reynoids, D J.]]

[[Category: Sharma, G.]]

[[Category: Smith, C C.]]

[[Category: Wang, L]]

[[Category: Wang, W.]]

[[Category: Wang, Z.]]

[[Category: Yuen, P.]]

[[Category: Zak, M.]]

[[Category: Zheng, X.]]

[[Category: Transferase]]

[[Category: Transferase-transferase inhibitor complex]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4lts|  PDB=4lts  |  SCENE=  }}
+===Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors===
+{{ABSTRACT_PUBMED_24279990}}
-The entry 4lts is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
-Authors: Zheng, X., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynoids, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Oh, A., Wang, W., Zak, M., Wang, Y., Yuen, P., Bair, K.W.
+==About this Structure==
+[[4lts]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LTS OCA].
-Description: Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
+==Reference==
+<ref group="xtra">PMID:024279990</ref><references group="xtra"/><references/>
+[[Category: Nicotinamide phosphoribosyltransferase]]
+[[Category: Bair, K W.]]
+[[Category: Baumeister, T.]]
+[[Category: Buckmelter, A J.]]
+[[Category: Caligiuri, M.]]
+[[Category: Clodfelter, K H.]]
+[[Category: Dragovich, P S.]]
+[[Category: Han, B.]]
+[[Category: Ho, Y.]]
+[[Category: Kley, N.]]
+[[Category: Lin, J.]]
+[[Category: Oh, A.]]
+[[Category: Reynoids, D J.]]
+[[Category: Sharma, G.]]
+[[Category: Smith, C C.]]
+[[Category: Wang, L]]
+[[Category: Wang, W.]]
+[[Category: Wang, Z.]]
+[[Category: Yuen, P.]]
+[[Category: Zak, M.]]
+[[Category: Zheng, X.]]
+[[Category: Transferase]]
+[[Category: Transferase-transferase inhibitor complex]]