4msg: Difference between revisions
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{{STRUCTURE_4msg| PDB=4msg | SCENE= }} | |||
===Crystal structure of tankyrase 1 with compound 22=== | |||
{{ABSTRACT_PUBMED_24294969}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TNKS1_HUMAN TNKS1_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.<ref>PMID:10988299</ref> <ref>PMID:11739745</ref> <ref>PMID:16076287</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> <ref>PMID:22864114</ref> | |||
==About this Structure== | |||
[[4msg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSG OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024294969</ref><references group="xtra"/><references/> | |||
[[Category: Huang, X.]] | |||
[[Category: Inhibitor]] | |||
[[Category: Parp]] | |||
[[Category: Tankyrase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
