4id4: Difference between revisions
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{{STRUCTURE_4id4| PDB=4id4 | SCENE= }} | |||
===Crystal structure of chimeric beta-lactamase cTEM-17m=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors. | |||
==About this Structure== | |||
[[4id4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ID4 OCA]. | |||
[[Category: Beta-lactamase]] | |||
[[Category: Berghuis, A M.]] | |||
[[Category: Gobeil, S.]] | |||
[[Category: Park, J.]] | |||
[[Category: Pelletier, J N.]] | |||
[[Category: Beta-lactamase]] | |||
[[Category: Hydrolase]] | |||
Revision as of 10:24, 25 December 2013
Crystal structure of chimeric beta-lactamase cTEM-17m
Function
[BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
About this Structure
4id4 is a 1 chain structure. Full crystallographic information is available from OCA.
