Sandbox Reserved 820: Difference between revisions

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<Structure load='2vaf' size='500' frame='true' align='right' caption='Crystal Structure of Human Cardiac Calsequestrin, (PDB code [[2vaf]]) ' scene='56/568018/General_structure/4'/>
<Structure load='2vaf' size='500' frame='true' align='right' caption='Crystal Structure of Human Cardiac Calsequestrin, (PDB code [[2vaf]]) ' scene='56/568018/General_structure/4'/>


'''
Calsequestrin-2 (or CASQ2) is the soluble CA2+ binding protein in the sarcoplasmic reticulum lumen of the cardiac muscle cells. CASQ2 could be either in a monomeric, homodimeric, or homooligomeric chain form depending on its bounds with Ca2+. Mutations of CASQ2 are involved in cardiac diseases such as Catecholaminergic Polymorphic Ventricular Tachycardia.
== Introduction ==
'''


Calsequestrin-2 (or CASQ2) is the soluble CA2+ binding protein in the sarcoplasmic reticulum lumen of the cardiac muscle cells. CASQ2 could be either in a monomeric, homodimeric, or homooligomeric chain form depending on its bounds with Ca2+. Mutations of CASQ2 are involved in cardiac diseases such as Catecholaminergic Polymorphic Ventricular Tachycardia.
[[Image:LoadBinary 004.gif|300px|left|thumb|Calsequestrin in the calcium cycle of myocyte contraction]]


== General Structure ==
== General Structure ==
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