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Calsequestrin-2 (or CASQ2) is the soluble CA2+ binding protein in the sarcoplasmic reticulum lumen of the cardiac muscle cells. CASQ2 could be either in a monomeric, homodimeric, or homooligomeric chain form depending on its bounds with Ca2+. Mutations of CASQ2 are involved in cardiac diseases such as Catecholaminergic Polymorphic Ventricular Tachycardia.

'''Calsequestrin-2''' (or '''CASQ2''') is the soluble CA2+ binding protein in the sarcoplasmic reticulum lumen of the cardiac muscle cells. CASQ2 could be either in a monomeric, homodimeric, or homooligomeric chain form depending on its bounds with Ca2+. Mutations of CASQ2 are involved in cardiac diseases such as Catecholaminergic Polymorphic Ventricular Tachycardia.

[[Image:LoadBinary 004.gif|300px|left|thumb|Calsequestrin in the calcium cycle of myocyte contraction]]

== General Structure ==

There are <scene name='56/568018/Alpha_helix/1'>12 alpha helix</scene> and <scene name='56/568018/Beta_sheet/2'>15 beta sheet</scene>.

<scene name='56/568018/Acidic_amino_acids/1'>The acidics amino acids</scene> can bind the Ca2+ especially the <scene name='56/568018/Glu/1'>glutamate</scene> and the <scene name='56/568018/Asp/1'>aspartate</scene>.

Sandbox Reserved 820: Difference between revisions

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 <!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
 <Structure load='2vaf' size='500' frame='true' align='right' caption='Crystal Structure of Human Cardiac Calsequestrin, (PDB code [[2vaf]]) ' scene='56/568018/General_structure/4'/>
-Calsequestrin-2 (or CASQ2) is the soluble CA2+ binding protein in the sarcoplasmic reticulum lumen of the cardiac muscle cells. CASQ2 could be either in a monomeric, homodimeric, or homooligomeric chain form depending on its bounds with Ca2+. Mutations of CASQ2 are involved in cardiac diseases such as Catecholaminergic Polymorphic Ventricular Tachycardia.
+'''Calsequestrin-2''' (or '''CASQ2''') is the soluble CA2+ binding protein in the sarcoplasmic reticulum lumen of the cardiac muscle cells. CASQ2 could be either in a monomeric, homodimeric, or homooligomeric chain form depending on its bounds with Ca2+. Mutations of CASQ2 are involved in cardiac diseases such as Catecholaminergic Polymorphic Ventricular Tachycardia.
 [[Image:LoadBinary 004.gif|300px|left|thumb|Calsequestrin in the calcium cycle of myocyte contraction]]
+{{clear}}
 == General Structure ==
 There are <scene name='56/568018/Alpha_helix/1'>12 alpha helix</scene> and <scene name='56/568018/Beta_sheet/2'>15 beta sheet</scene>.
 <scene name='56/568018/Acidic_amino_acids/1'>The acidics amino acids</scene> can bind the Ca2+ especially the <scene name='56/568018/Glu/1'>glutamate</scene> and the <scene name='56/568018/Asp/1'>aspartate</scene>.