Sandbox Reserved 828: Difference between revisions
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*a <scene name='56/568026/Tower/1'>tower domain</scene> with alpha/beta structure that participates in DNA bending during cleavage. | *a <scene name='56/568026/Tower/1'>tower domain</scene> with alpha/beta structure that participates in DNA bending during cleavage. | ||
The ‘head’ dimer interface is dominated by an antiparallel side by-side packing of the <scene name='56/568026/Alpha3/2'>alpha 3</scene> (the first helix of the HTH motif) from each monomer, together with their adjoining loops. At the top of the interface, the ‘recognition’ helices <scene name='56/568026/Alpha4/1'> | The '''‘head’ dimer interface is dominated by an antiparallel side by-side packing of the <scene name='56/568026/Alpha3/2'>alpha 3</scene> (the first helix of the HTH motif) from each monomer''', together with their adjoining loops. At the top of the interface, '''the ‘recognition’ helices <scene name='56/568026/Alpha4/1'>alpha 4</scene> make a head-to-head antiparallel dimer contact.''' | ||
There is a <scene name='56/568026/Coiledcoil_141819/1'>Coiled-coil</scene> domain, folowing the tower, with a helical core at the tail region. Two long helices ( | There is a '''<scene name='56/568026/Coiledcoil_141819/1'>Coiled-coil</scene> domain''', folowing the tower, with a helical core at the tail region. Two long helices ( | ||
<scene name='56/568026/Helix14/1'>alpha helix 14</scene> and <scene name='56/568026/Helix18/1'>alpha helix 18</scene>) emanate from this core and connect, together with the C-terminal helix ( | <scene name='56/568026/Helix14/1'>alpha helix 14</scene> and <scene name='56/568026/Helix18/1'>alpha helix 18</scene>) emanate from this core and connect, together with the C-terminal helix ( | ||
<scene name='56/568026/Helix19/1'>alpha helix 19</scene>), the head and tail fragments. This domain has a small globular domain at it's end and is involved in the dimerization creating the <scene name='56/568026/Coiledcoil/1'>C-gate</scene> . | <scene name='56/568026/Helix19/1'>alpha helix 19</scene>), the head and tail fragments. This domain has a small globular domain at it's end and is '''involved in the dimerization creating the <scene name='56/568026/Coiledcoil/1'>C-gate</scene>.''' | ||
The three connecting helices (α14,α18 and α19) adopt very different conformations, leading to large quaternary movements involving a single hinge-point within the helices and rigid body movements of | The '''three connecting helices (<scene name='56/568026/Helix14/1'>α14</scene>, <scene name='56/568026/Helix18/1'>α18</scene> and <scene name='56/568026/Helix19/1'>α19</scene>)''' adopt very different conformations, leading to '''large quaternary movements''' involving a single hinge-point within the helices and '''rigid body movements of the head fragments.''' | ||
the head fragments. | |||
[[Image:helixrot.jpg]] [[Image:gyrA592.jpg]] | [[Image:helixrot.jpg]] [[Image:gyrA592.jpg]] | ||
